Sanofi (SNY) FY 2025 Review
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Boring is the New Beautiful
By Nathan Brinkman
Sanofi (SNY) is a French multinational biopharmaceutical company and one of the largest pharmaceutical companies in the world by revenue. SNY is headquartered in Paris with a significant commercial and R&D presence in the United States, which accounts for roughly 45% of its total sales. Founded in 1973 and transformed through decades of mergers and acquisitions, most notably the 2004 combination of Sanofi-Synthélabo and Aventis, the company has evolved from a diversified healthcare conglomerate into a focused, science-driven biopharma with four core therapeutic priorities: Immunology, Rare Diseases, Neurology, and Oncology, alongside a world-class Vaccines franchise operated through its Sanofi Pasteur division.
Today, the company's revenue engine is anchored by Dupixent (dupilumab), a blockbuster biologic co-developed and co-commercialized with Regeneron (REGN) that generated €15.7 billion in 2025 sales across indications including atopic dermatitis, asthma, COPD, and eosinophilic esophagitis. Beyond Dupixent, Sanofi's commercial portfolio includes Beyfortus (a first-in-class RSV prevention antibody for infants), a leading Vaccines business generating nearly €8 billion annually, and a growing slate of recently launched medicines in rare blood disorders and immunology. Following the April 2025 divestiture of its Opella consumer health division for approximately €10 billion, Sanofi now operates as a pure-play biopharma, redeploying that capital aggressively into pipeline development and strategic acquisitions — with over 94 clinical programs underway and an ambition to reach $80 billion in revenue by the end of the decade
The Vaccines franchise was further strengthened in early 2026 with the completed acquisition of Dynavax Technologies (DVAX) for approximately $2.2 billion, adding HEPLISAV-B and a Phase 1/2 shingles vaccine candidate (Z-1018) that has shown comparable immune responses to the current market leader with a potentially improved tolerability profile.
This combination of predictable revenue, durable franchise assets, three decades of consecutive dividend growth, and an accelerating pipeline positions Sanofi as a rare blend of defensive stability and growth optionality in the large-cap pharmaceutical space.
What makes SNY boring, yet beautiful?